Version 5.4
Homo sapiens Protein: UGGT1
Summary
InnateDB Protein IDBP-69475.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UGGT1
Protein Name UDP-glucose glycoprotein glucosyltransferase 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000259253
InnateDB Gene IDBG-69471 (UGGT1)
Protein Structure
UniProt Annotation
Function Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation. {ECO:0000269PubMed:10694380}.
Subcellular Localization Endoplasmic reticulum lumen {ECO:0000255PROSITE-ProRule:PRU10138, ECO:0000269PubMed:10694380}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000255PROSITE-ProRule:PRU10138, ECO:0000269PubMed:10694380}.
Disease Associations
Tissue Specificity Higher levels in pancreas, skeletal muscle, kidney, and brain. Low levels in lung and heart. {ECO:0000269PubMed:10694380}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 31 [view]
Protein-Protein 31 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity
GO:0005515 protein binding
GO:0051082 unfolded protein binding
Biological Process
GO:0006457 protein folding
GO:0006486 protein glycosylation
GO:0018279 protein N-linked glycosylation via asparagine
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0051084 'de novo' posttranslational protein folding
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR009448 UDP-glucose:Glycoprotein Glucosyltransferase
IPR029044 Nucleotide-diphospho-sugar transferases
PFAM PF06427
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NYU2
PhosphoSite PhosphoSite-Q9NYU2
TrEMBL
UniProt Splice Variant
Entrez Gene 56886
UniGene Hs.743306
RefSeq NP_064505
HUGO HGNC:15663
OMIM 605897
CCDS CCDS2154
HPRD 12064
IMGT
EMBL AC017079 AC108059 AF227905 AK023671 BC041098
GenPept AAF66232 AAH41098 AAY14735 AAY14885 BAB14632

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca