InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CSRP3

Summary

InnateDB Protein

IDBP-694822.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CSRP3

Protein Name

Cysteine and glycine-rich protein 3

Synonyms

CRP3;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000030304

InnateDB Gene

IDBG-642370 (CSRP3)

Protein Structure

UniProt Annotation

Function

Positive regulator of myogenesis. Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000305}. Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000305}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}. Note=Mainly cytoplasmic (By similarity). In the nucleus it associates with the actin cytoskeleton (Potential). In the Z line, found associated with GLRX3 (By similarity). {ECO:0000250, ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0008307	structural constituent of muscle
GO:0031433	telethonin binding
GO:0042805	actinin binding
GO:0046872	metal ion binding

Biological Process

GO:0002026	regulation of the force of heart contraction
GO:0003300	cardiac muscle hypertrophy
GO:0006874	cellular calcium ion homeostasis
GO:0007275	multicellular organismal development
GO:0007517	muscle organ development
GO:0030154	cell differentiation
GO:0033365	protein localization to organelle
GO:0035995	detection of muscle stretch
GO:0048738	cardiac muscle tissue development
GO:0055003	cardiac myofibril assembly
GO:0060048	cardiac muscle contraction

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0030018	Z disc

Protein Structure and Domains

PDB ID

InterPro

IPR001781 Zinc finger, LIM-type

PFAM

PF00412

PRINTS

PIRSF

SMART

SM00132

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q4U0T9

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

540407

UniGene

RefSeq

NP_001019860

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC103108 DQ022067

GenPept

AAI03109 AAY45897