Version 5.4
Bos taurus Protein: FSCN2
Summary
InnateDB Protein IDBP-694978.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FSCN2
Protein Name Fascin-2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000034620
InnateDB Gene IDBG-642519 (FSCN2)
Protein Structure
UniProt Annotation
Function Acts as an actin bundling protein. May play a pivotal role in photoreceptor cell-specific events, such as disk morphogenesis.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, stereocilium {ECO:0000250}.
Disease Associations
Tissue Specificity Exclusively expressed in the eye, specifically in photoreceptor cells.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0030674 protein binding, bridging
GO:0051015 actin filament binding
Biological Process
GO:0030036 actin cytoskeleton organization
GO:0042462 eye photoreceptor cell development
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0015629 actin cytoskeleton
GO:0032420 stereocilium
GO:0042995 cell projection
Protein Structure and Domains
PDB ID
InterPro IPR008999 Actin cross-linking
IPR010414 FRG1-like
IPR022768 Fascin domain
PFAM PF06229
PF06268
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O18728
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 337926
UniGene Bt.490
RefSeq NP_788806
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AB003485
GenPept BAA22637

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca