|
InnateDB Protein
|
IDBP-696191.3
|
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
|
Gene Symbol
|
RPRD1A
|
|
Protein Name
|
Regulation of nuclear pre-mRNA domain-containing protein 1A
|
|
Synonyms
|
P15RS;
|
|
Species
|
Bos taurus
|
|
Ensembl Protein
|
ENSBTAP00000048688
|
|
InnateDB Gene
|
IDBG-643624 (RPRD1A)
|
|
Protein Structure
|
|
| Function |
Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle (By similarity). {ECO:0000250}.
|
| Subcellular Localization |
|
| Disease Associations |
|
| Tissue Specificity |
|
| Comments |
|
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
|
|
| Predicted by orthology |
| Total |
5 [view]
|
|
|
Molecular Function |
|
| Biological Process |
|
GO:0070940
|
dephosphorylation of RNA polymerase II C-terminal domain
|
|
| Cellular Component |
|
GO:0016591
|
DNA-directed RNA polymerase II, holoenzyme
|
|
| PDB ID |
|
| InterPro |
IPR006569
CID domain
IPR006903
RNA polymerase II-binding domain
IPR008942
ENTH/VHS
|
| PFAM |
PF04818
|
| PRINTS |
|
| PIRSF |
|
| SMART |
SM00582
|
| TIGRFAMs |
|
| Modification |
|
| SwissProt |
Q0P5J9
|
| PhosphoSite |
PhosphoSite-
|
| TrEMBL |
|
| UniProt Splice Variant |
|
| Entrez Gene |
504355
|
| UniGene |
Bt.74401
|
| RefSeq |
NP_001068624
|
| HUGO |
|
| OMIM |
|
| CCDS |
|
| HPRD |
|
| IMGT |
|
| EMBL |
BC119944
|
| GenPept |
AAI19945
|
|
|
|
Version 5.4