InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: EGFR

Summary

InnateDB Protein

IDBP-696638.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EGFR

Protein Name

epidermal growth factor receptor

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000015445

InnateDB Gene

IDBG-644035 (EGFR)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 336 interaction(s) predicted by orthology.

Predicted by orthology
Total	336 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003682	chromatin binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0004716	receptor signaling protein tyrosine kinase activity
GO:0004871	signal transducer activity
GO:0004888	transmembrane signaling receptor activity
GO:0005006	epidermal growth factor-activated receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019899	enzyme binding
GO:0019903	protein phosphatase binding
GO:0030235	nitric-oxide synthase regulator activity
GO:0042802	identical protein binding
GO:0046982	protein heterodimerization activity
GO:0051015	actin filament binding

Biological Process

GO:0000902	cell morphogenesis
GO:0001892	embryonic placenta development
GO:0001934	positive regulation of protein phosphorylation
GO:0001942	hair follicle development
GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007435	salivary gland morphogenesis
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0008544	epidermis development
GO:0016310	phosphorylation
GO:0016337	single organismal cell-cell adhesion
GO:0021795	cerebral cortex cell migration
GO:0023014	signal transduction by phosphorylation
GO:0030335	positive regulation of cell migration
GO:0031659	positive regulation of cyclin-dependent protein kinase activity involved in G1/S
GO:0035413	positive regulation of catenin import into nucleus
GO:0042127	regulation of cell proliferation
GO:0042177	negative regulation of protein catabolic process
GO:0042327	positive regulation of phosphorylation
GO:0043066	negative regulation of apoptotic process
GO:0043406	positive regulation of MAP kinase activity
GO:0045429	positive regulation of nitric oxide biosynthetic process
GO:0045739	positive regulation of DNA repair
GO:0045740	positive regulation of DNA replication
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046777	protein autophosphorylation
GO:0048146	positive regulation of fibroblast proliferation
GO:0048546	digestive tract morphogenesis
GO:0050679	positive regulation of epithelial cell proliferation
GO:0050730	regulation of peptidyl-tyrosine phosphorylation
GO:0050999	regulation of nitric-oxide synthase activity
GO:0051897	positive regulation of protein kinase B signaling
GO:0060571	morphogenesis of an epithelial fold
GO:0070141	response to UV-A
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0071230	cellular response to amino acid stimulus
GO:0071392	cellular response to estradiol stimulus

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0030139	endocytic vesicle
GO:0043235	receptor complex
GO:0045121	membrane raft
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000494 EGF receptor, L domain
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR006211 Furin-like cysteine-rich domain
IPR006212 Furin-like repeat
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR011009 Protein kinase-like domain
IPR016245 Tyrosine protein kinase, EGF/ERB/XmrK receptor
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF01030
PF00069
PF07714
PF00757

PRINTS

PR00109

PIRSF

PIRSF000619

SMART

SM00220
SM00261
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References