Version 5.4
Bos taurus Protein: FECH
Summary
InnateDB Protein IDBP-697481.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FECH
Protein Name Ferrochelatase, mitochondrial
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000008384
InnateDB Gene IDBG-644814 (FECH)
Protein Structure
UniProt Annotation
Function Catalyzes the ferrous insertion into protoporphyrin IX.
Subcellular Localization Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004325 ferrochelatase activity
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0016829 lyase activity
GO:0020037 heme binding
GO:0030350 iron-responsive element binding
GO:0046872 metal ion binding
GO:0046906 tetrapyrrole binding
GO:0051536 iron-sulfur cluster binding
GO:0051537 2 iron, 2 sulfur cluster binding
Biological Process
GO:0006779 porphyrin-containing compound biosynthetic process
GO:0006783 heme biosynthetic process
GO:0008203 cholesterol metabolic process
GO:0009416 response to light stimulus
GO:0009589 detection of UV
GO:0010468 regulation of gene expression
GO:0010999 regulation of eIF2 alpha phosphorylation by heme
GO:0030218 erythrocyte differentiation
GO:0034379 very-low-density lipoprotein particle assembly
GO:0046501 protoporphyrinogen IX metabolic process
GO:0046984 regulation of hemoglobin biosynthetic process
GO:0055072 iron ion homeostasis
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR001015 Ferrochelatase
PFAM PF00762
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P22600
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281158
UniGene Bt.88608
RefSeq NP_776479
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL L34173
GenPept AAA79169

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca