InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: IGF2

Summary

InnateDB Protein

IDBP-697936.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IGF2

Protein Name

Insulin-like growth factor IIInsulin-like growth factor IIPreptin

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000017372

InnateDB Gene

IDBG-645244 (IGF2)

Protein Structure

UniProt Annotation

Function

The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development.Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3 (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005158	insulin receptor binding
GO:0005159	insulin-like growth factor receptor binding
GO:0005179	hormone activity
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0030546	receptor activator activity
GO:0043539	protein serine/threonine kinase activator activity

Biological Process

GO:0001503	ossification
GO:0001649	osteoblast differentiation
GO:0001934	positive regulation of protein phosphorylation
GO:0005975	carbohydrate metabolic process
GO:0006006	glucose metabolic process
GO:0009887	organ morphogenesis
GO:0031017	exocrine pancreas development
GO:0038028	insulin receptor signaling pathway via phosphatidylinositol 3-kinase
GO:0042104	positive regulation of activated T cell proliferation
GO:0043085	positive regulation of catalytic activity
GO:0043410	positive regulation of MAPK cascade
GO:0045725	positive regulation of glycogen biosynthetic process
GO:0045840	positive regulation of mitosis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046628	positive regulation of insulin receptor signaling pathway
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0051146	striated muscle cell differentiation
GO:0051781	positive regulation of cell division
GO:0051897	positive regulation of protein kinase B signaling
GO:0071902	positive regulation of protein serine/threonine kinase activity
GO:2000273	positive regulation of receptor activity
GO:2000467	positive regulation of glycogen (starch) synthase activity

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR013576 Insulin-like growth factor II E-peptide, C-terminal
IPR016179 Insulin-like
IPR022334 Insulin-like growth factor II
IPR022350 Insulin-like growth factor
IPR022352 Insulin family

PFAM

PF08365
PF00049

PRINTS

PR02006
PR02002
PR00276

PIRSF

SMART

SM00078

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt