Version 5.4
| Bos taurus Protein: IGF2 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-697937.2 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | IGF2 | ||||||||
| Protein Name | Insulin-like growth factor IIInsulin-like growth factor IIPreptin | ||||||||
| Synonyms | |||||||||
| Species | Bos taurus | ||||||||
| Ensembl Protein | ENSBTAP00000041652 | ||||||||
| InnateDB Gene | IDBG-645244 (IGF2) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development.Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3 (By similarity). {ECO:0000250}. | ||||||||
| Subcellular Localization | Secreted. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | |||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | |||||||||
| InterPro |
IPR013576
Insulin-like growth factor II E-peptide, C-terminal IPR016179 Insulin-like IPR022334 Insulin-like growth factor II IPR022350 Insulin-like growth factor IPR022352 Insulin family |
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| PFAM |
PF08365
PF00049 |
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| PRINTS |
PR02006
PR02002 PR00276 |
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| PIRSF | |||||||||
| SMART |
SM00078
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | P07456 | ||||||||
| PhosphoSite | PhosphoSite- | ||||||||
| TrEMBL | Q862E7 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 281240 | ||||||||
| UniGene | Bt.30727 | ||||||||
| RefSeq | |||||||||
| HUGO | |||||||||
| OMIM | |||||||||
| CCDS | |||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AB099052 AY957981 BC116039 DQ298740 DQ298741 DQ298742 DQ298743 DQ298744 DQ298745 DQ298746 DQ298747 DQ298749 EU518675 HQ703509 X53553 X53867 | ||||||||
| GenPept | AAI16040 ABB99965 ABB99966 ABB99967 ABB99968 ABB99969 ABB99970 ABB99971 ABB99972 ABB99973 ABD34310 ACD35247 AEX15868 BAC56542 CAA37620 CAA37861 | ||||||||