InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: MANF

Summary

InnateDB Protein

IDBP-698515.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MANF

Protein Name

Mesencephalic astrocyte-derived neurotrophic factor

Synonyms

ARMET;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000042500

InnateDB Gene

IDBG-645769 (MANF)

Protein Structure

UniProt Annotation

Function

Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons. Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008083	growth factor activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0002014	vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure
GO:0006986	response to unfolded protein

Cellular Component

GO:0005576	extracellular region
GO:0005634	nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR011001 Saposin-like
IPR019345 Armet protein

PFAM

PF10208

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P80513

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

540432

UniGene

RefSeq

NP_001094681

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC149246

GenPept

AAI49247