InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CCNY

Summary

InnateDB Protein

IDBP-69879.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCNY

Protein Name

cyclin Y

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000344275

InnateDB Gene

IDBG-69871 (CCNY)

Protein Structure

UniProt Annotation

Function

Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription. {ECO:0000269PubMed:18060517, ECO:0000269PubMed:19524571, ECO:0000269PubMed:20059949, ECO:0000269PubMed:22184064}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:18060517, ECO:0000269PubMed:19524571, ECO:0000269PubMed:20059949, ECO:0000269PubMed:22184064}; Lipid-anchor {ECO:0000269PubMed:18060517, ECO:0000269PubMed:19524571, ECO:0000269PubMed:20059949, ECO:0000269PubMed:22184064}; Cytoplasmic side {ECO:0000269PubMed:18060517, ECO:0000269PubMed:19524571, ECO:0000269PubMed:20059949, ECO:0000269PubMed:22184064}.Isoform 3: Nucleus.

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:18060517}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity
GO:0019901	protein kinase binding

Biological Process

GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000086	G2/M transition of mitotic cell cycle
GO:0016055	Wnt signaling pathway
GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0051301	cell division
GO:0060828	regulation of canonical Wnt signaling pathway

Cellular Component

GO:0000308	cytoplasmic cyclin-dependent protein kinase holoenzyme complex
GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0070062	extracellular vesicular exosome