Version 5.4
Bos taurus Protein: IL12B
Summary
InnateDB Protein IDBP-699226.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL12B
Protein Name Interleukin-12 subunit beta
Synonyms IL12p40;
Species Bos taurus
Ensembl Protein ENSBTAP00000006222
InnateDB Gene IDBG-646420 (IL12B)
Protein Structure
UniProt Annotation
Function Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine- activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. {ECO:0000250}.Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak- Stat signaling cascade, stimulates memory rather than naive T- cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis (By similarity). {ECO:0000250}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
Predicted by orthology
Total 27 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004896 cytokine receptor activity
GO:0005125 cytokine activity
GO:0005126 cytokine receptor binding
GO:0005143 interleukin-12 receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0042164 interleukin-12 alpha subunit binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0045519 interleukin-23 receptor binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0001916 positive regulation of T cell mediated cytotoxicity
GO:0002230 positive regulation of defense response to virus by host
GO:0002827 positive regulation of T-helper 1 type immune response
GO:0002860 positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0007050 cell cycle arrest
GO:0007166 cell surface receptor signaling pathway
GO:0010224 response to UV-B
GO:0010535 positive regulation of activation of JAK2 kinase activity
GO:0016477 cell migration
GO:0019221 cytokine-mediated signaling pathway
GO:0030101 natural killer cell activation
GO:0032693 negative regulation of interleukin-10 production
GO:0032700 negative regulation of interleukin-17 production
GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032729 positive regulation of interferon-gamma production
GO:0032733 positive regulation of interleukin-10 production
GO:0032735 positive regulation of interleukin-12 production
GO:0032740 positive regulation of interleukin-17 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032816 positive regulation of natural killer cell activation
GO:0032819 positive regulation of natural killer cell proliferation
GO:0032946 positive regulation of mononuclear cell proliferation
GO:0034393 positive regulation of smooth muscle cell apoptotic process
GO:0042093 T-helper cell differentiation
GO:0042095 interferon-gamma biosynthetic process
GO:0042102 positive regulation of T cell proliferation
GO:0042104 positive regulation of activated T cell proliferation
GO:0042510 regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042520 positive regulation of tyrosine phosphorylation of Stat4 protein
GO:0042523 positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0042832 defense response to protozoan
GO:0044130 negative regulation of growth of symbiont in host
GO:0045672 positive regulation of osteoclast differentiation
GO:0045785 positive regulation of cell adhesion
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0050671 positive regulation of lymphocyte proliferation
GO:0050829 defense response to Gram-negative bacterium
GO:0051135 positive regulation of NK T cell activation
GO:0051142 positive regulation of NK T cell proliferation
GO:0051607 defense response to virus
GO:0071222 cellular response to lipopolysaccharide
GO:0071346 cellular response to interferon-gamma
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0043514 interleukin-12 complex
GO:0070743 interleukin-23 complex
Protein Structure and Domains
PDB ID
InterPro IPR003598 Immunoglobulin subtype 2
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like domain
IPR015528 Interleukin-12 beta
IPR019482 Interleukin-12 beta, central domain
PFAM PF00041
PF01108
PF10420
PRINTS PR01928
PIRSF PIRSF038007
SMART SM00408
SM00060
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P46282
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281857
UniGene Bt.523
RefSeq NP_776781
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL EU276076 U11815
GenPept AAA85792 ABX72074

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca