InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: NUDT12

Summary

InnateDB Protein

IDBP-699438.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NUDT12

Protein Name

Peroxisomal NADH pyrophosphatase NUDT12

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000039749

InnateDB Gene

IDBG-646617 (NUDT12)

Protein Structure

UniProt Annotation

Function

Hydrolyzes NAD(P)H to NMNH and AMP (2',5'-ADP), and diadenosine diphosphate to AMP. Has also activity towards NAD(P)(+), ADP-ribose and diadenosine triphosphate. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle (By similarity). {ECO:0000250}.

Subcellular Localization

Peroxisome {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000210	NAD+ diphosphatase activity
GO:0016787	hydrolase activity
GO:0035529	NADH pyrophosphatase activity
GO:0046872	metal ion binding

Biological Process

GO:0006742	NADP catabolic process
GO:0019677	NAD catabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005777	peroxisome

Protein Structure and Domains

PDB ID

InterPro

IPR000086 NUDIX hydrolase domain
IPR015375 NADH pyrophosphatase-like, N-terminal
IPR015376 Zinc ribbon, NADH pyrophosphatase
IPR015797 NUDIX hydrolase domain-like
IPR020683 Ankyrin repeat-containing domain

PFAM

PF00293
PF09296
PF09297
PF11929
PF12796

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q29RH3

PhosphoSite