Version 5.4
Homo sapiens Protein: HRASLS
Summary
InnateDB Protein IDBP-69946.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HRASLS
Protein Name HRAS-like suppressor
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000264735
InnateDB Gene IDBG-69944 (HRASLS)
Protein Structure
UniProt Annotation
Function Exhibits calcium-independent phospholipase activity towards phosphatidylcholine (PC) and phosphatidylethanolamine (PE). Also shows acyltransferase activities, transferring an acyl group of PCs to the amino group of PEs and the hydroxyl group of lyso PCs. {ECO:0000269PubMed:21880860}.
Subcellular Localization Membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Abundantly expressed in testis, skeletal muscle, brain, and heart. {ECO:0000269PubMed:21880860}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004620 phospholipase activity
GO:0016740 transferase activity
GO:0016787 hydrolase activity
Biological Process
GO:0007031 peroxisome organization
GO:0016042 lipid catabolic process
GO:0046485 ether lipid metabolic process
Cellular Component
GO:0005641 nuclear envelope lumen
GO:0005737 cytoplasm
GO:0005777 peroxisome
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR007053 LRAT-like domain
PFAM PF04970
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9HDD0
PhosphoSite PhosphoSite-
TrEMBL X6R3D1
UniProt Splice Variant
Entrez Gene 57110
UniGene Hs.36761
RefSeq NP_065119
HUGO HGNC:14922
OMIM 606487
CCDS CCDS3303
HPRD 07577
IMGT
EMBL AB030816 AB510981 AC092966 AC105057 CH471052
GenPept BAB08110 BAI63210 EAW78078 EAW78079

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca