InnateDB Protein
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IDBP-699943.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CDK5R1
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Protein Name
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Cyclin-dependent kinase 5 activator 1Cyclin-dependent kinase 5 activator 1, p35Cyclin-dependent kinase 5 activator 1, p25
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Synonyms
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P25/P35;
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000052270
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InnateDB Gene
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IDBG-647094 (CDK5R1)
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Protein Structure
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Function |
p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cyclin-dependent kinase 5 activator 1, p35: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}.Cyclin-dependent kinase 5 activator 1, p25: Nucleus {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Note=The conversion of p35 to p25 relocalizes the protein from the cell periphery to the cytoplasm, in nuclear and perinuclear regions. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Brain and neuron specific.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Experimentally validated |
Total |
5
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
28 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR004944
Cyclin-dependent kinase 5 activator
IPR013763
Cyclin-like
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PFAM |
PF03261
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PRINTS |
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PIRSF |
PIRSF009324
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SMART |
SM00385
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TIGRFAMs |
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Modification |
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SwissProt |
Q28199
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
282173
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UniGene |
Bt.103335
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RefSeq |
NP_776937
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HUGO |
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
BC122779
S73375
X78883
X78934
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GenPept |
AAB31984
AAI22780
CAA55481
CAA55534
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