Version 5.4
Homo sapiens Protein: EPS8L1
Summary
InnateDB Protein IDBP-70007.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EPS8L1
Protein Name EPS8-like 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000201647
InnateDB Gene IDBG-70003 (EPS8L1)
Protein Structure
UniProt Annotation
Function Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. {ECO:0000269PubMed:14565974}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:14565974}.
Disease Associations
Tissue Specificity Detected in placenta. {ECO:0000269PubMed:14565974}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0016301 kinase activity
GO:0030676 Rac guanyl-nucleotide exchange factor activity
GO:0042608 T cell receptor binding
Biological Process
GO:0007266 Rho protein signal transduction
GO:0016310 phosphorylation
GO:0032321 positive regulation of Rho GTPase activity
GO:0032855 positive regulation of Rac GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:1900029 positive regulation of ruffle assembly
Cellular Component
GO:0005737 cytoplasm
GO:0032587 ruffle membrane
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001452 SH3 domain
IPR006020 PTB/PI domain
IPR011511 Variant SH3 domain
IPR013625 Tensin phosphotyrosine-binding domain
IPR013761 Sterile alpha motif/pointed domain
PFAM PF00018
PF14604
PF00640
PF14719
PF07653
PF08416
PRINTS PR00452
PIRSF
SMART SM00326
SM00462
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TE68
PhosphoSite PhosphoSite-Q8TE68
TrEMBL B4DKV7
UniProt Splice Variant
Entrez Gene 54869
UniGene Hs.438862
RefSeq NP_573441
HUGO HGNC:21295
OMIM 614987
CCDS CCDS12914
HPRD 13276
IMGT
EMBL AC005782 AC011476 AF282167 AF282168 AF370395 AK000265 AK075098 AK296732 AY074928 BC004907 BC015763
GenPept AAG03038 AAG03039 AAH04907 AAH15763 AAL76117 AAQ15231 BAA91041 BAC11399 BAG59319

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca