InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PTPRH

Summary

InnateDB Protein

IDBP-70384.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTPRH

Protein Name

protein tyrosine phosphatase, receptor type, H

Synonyms

R-PTP-H; SAP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000365528

InnateDB Gene

IDBG-70382 (PTPRH)

Protein Structure

UniProt Annotation

Function

May contribute to contact inhibition of cell growth and motility by mediating the dephosphorylation of focal adhesion- associated substrates and thus negatively regulating integrin- promoted signaling processes. Induces apoptotic cell death by at least two distinct mechanisms: inhibition of cell survival signaling mediated by PI 3-kinase, Akt, and ILK and activation of a caspase-dependent proapoptotic pathway. Inhibits the basal activity of LCK and its activation in response to TCR stimulation and TCR-induced activation of MAP kinase and surface expression of CD69. Inhibits TCR-induced tyrosine phosphorylation of LAT and ZAP70. Inhibits both basal activity of DOK1 and its CD2-induced tyrosine phosphorylation. Induces dephosphorylation of p130cas, focal adhesion kinase and c-Src. Reduces migratory activity of Jurkat cells. {ECO:0000269PubMed:11278335, ECO:0000269PubMed:12101188, ECO:0000269PubMed:12837766, ECO:0000269PubMed:15850787}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269PubMed:12879010}.

Disease Associations

Tissue Specificity

Expressed at high levels in the brain, spleen and liver and at lower levels in the heart and stomach. Expressed in pancreatic and colorectal cancer cells, but not in normal pancreas or colon. Expression in hepatocellular carcinoma is related to the differentiation status of the tumor and expression is inversely related to tumor aggressiveness. {ECO:0000269PubMed:12837766, ECO:0000269PubMed:12879010, ECO:0000269PubMed:8294459}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0016791	phosphatase activity

Biological Process

GO:0006470	protein dephosphorylation
GO:0006915	apoptotic process
GO:0016311	dephosphorylation
GO:0035335	peptidyl-tyrosine dephosphorylation

Cellular Component

GO:0005737	cytoplasm
GO:0005887	integral component of plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR003961 Fibronectin, type III
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102
PF00041
PF01108

PRINTS

PR00700

PIRSF

SMART

SM00194
SM00404
SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt