Version 5.4
Homo sapiens Protein: LSG1
Summary
InnateDB Protein IDBP-70419.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LSG1
Protein Name large subunit GTPase 1 homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000265245
InnateDB Gene IDBG-70417 (LSG1)
Protein Structure
UniProt Annotation
Function GTPase required for the XPO1/CRM1-mediated nuclear export of the 60S ribosomal subunit. Probably acts by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm (Probable). {ECO:0000305PubMed:16209721}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:16209721}. Endoplasmic reticulum {ECO:0000269PubMed:16209721}. Nucleus, Cajal body {ECO:0000269PubMed:16209721}. Note=Shuttles between the Cajal bodies in the nucleus and the endoplasmic reticulum.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 3 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0006184 GTP catabolic process
GO:0015031 protein transport
GO:0042254 ribosome biogenesis
GO:0051168 nuclear export
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0015030 Cajal body
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR006073 GTP binding domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF01926
PRINTS PR00326
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H089
PhosphoSite PhosphoSite-Q9H089
TrEMBL
UniProt Splice Variant
Entrez Gene 55341
UniGene Hs.738399
RefSeq NP_060855
HUGO HGNC:25652
OMIM 610780
CCDS CCDS33922
HPRD 07748
IMGT
EMBL AC046143 AK002163 AL136897 BC015042 BC040119 BC068500
GenPept AAH15042 AAH40119 AAH68500 BAA92116 CAB66831

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca