Version 5.4
Homo sapiens Protein: TK1
Summary
InnateDB Protein IDBP-70502.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TK1
Protein Name thymidine kinase 1, soluble
Synonyms TK2;
Species Homo sapiens
Ensembl Protein ENSP00000301634
InnateDB Gene IDBG-70500 (TK1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Cytoplasm.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 317 experimentally validated interaction(s) in this database.
Experimentally validated
Total 317 [view]
Protein-Protein 314 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004797 thymidine kinase activity
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0019206 nucleoside kinase activity
GO:0042802 identical protein binding
Biological Process
GO:0001889 liver development
GO:0006139 nucleobase-containing compound metabolic process
GO:0006206 pyrimidine nucleobase metabolic process
GO:0006260 DNA replication
GO:0009157 deoxyribonucleoside monophosphate biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0009636 response to toxic substance
GO:0014856 skeletal muscle cell proliferation
GO:0016310 phosphorylation
GO:0031667 response to nutrient levels
GO:0043097 pyrimidine nucleoside salvage
GO:0044281 small molecule metabolic process
GO:0046104 thymidine metabolic process
GO:0046688 response to copper ion
GO:0048565 digestive tract development
GO:0051289 protein homotetramerization
GO:0051414 response to cortisol
GO:0055086 nucleobase-containing small molecule metabolic process
GO:0060138 fetal process involved in parturition
Cellular Component
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR001267 Thymidine kinase
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00265
PRINTS
PIRSF PIRSF035805
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P04183
PhosphoSite PhosphoSite-P04183
TrEMBL A0A024R8N6
UniProt Splice Variant
Entrez Gene 7083
UniGene Hs.624417
RefSeq NP_003249
HUGO HGNC:11830
OMIM 188300
CCDS CCDS11754
HPRD 01771
IMGT
EMBL AK314950 BC006484 BC007872 BC007986 BT006941 CH471099 K02581 M13643 M15205
GenPept AAA61187 AAA61189 AAA61191 AAH06484 AAH07872 AAH07986 AAP35587 BAG37455 EAW89505 EAW89508

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca