InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: APOD

Summary

InnateDB Protein

IDBP-70580.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APOD

Protein Name

apolipoprotein D

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000345179

InnateDB Gene

IDBG-70578 (APOD)

Protein Structure

UniProt Annotation

Function

APOD occurs in the macromolecular complex with lecithin- cholesterol acyltransferase. It is probably involved in the transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Expressed in liver, intestine, pancreas, kidney, placenta, adrenal, spleen, fetal brain tissue and tears.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005319	lipid transporter activity
GO:0005515	protein binding
GO:0008289	lipid binding
GO:0015485	cholesterol binding

Biological Process

GO:0000302	response to reactive oxygen species
GO:0001525	angiogenesis
GO:0006006	glucose metabolic process
GO:0006629	lipid metabolic process
GO:0006810	transport
GO:0006869	lipid transport
GO:0007420	brain development
GO:0007568	aging
GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway
GO:0014012	peripheral nervous system axon regeneration
GO:0030682	evasion or tolerance of host defense response
GO:0042246	tissue regeneration
GO:0042308	negative regulation of protein import into nucleus
GO:0042493	response to drug
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0048678	response to axon injury
GO:0051895	negative regulation of focal adhesion assembly
GO:0060588	negative regulation of lipoprotein lipid oxidation
GO:0071638	negative regulation of monocyte chemotactic protein-1 production
GO:1900016	negative regulation of cytokine production involved in inflammatory response
GO:2000098	negative regulation of smooth muscle cell-matrix adhesion
GO:2000405	negative regulation of T cell migration

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005783	endoplasmic reticulum
GO:0022626	cytosolic ribosome
GO:0030425	dendrite
GO:0043025	neuronal cell body
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000566 Lipocalin/cytosolic fatty-acid binding domain
IPR002345 Lipocalin
IPR002446 Lipocalin, bacterial
IPR002969 Apolipoprotein D
IPR003057 Invertebrate colouration protein
IPR005657 Triabin, pallidipin/procalin
IPR011038 Calycin-like
IPR022271 Lipocalin, ApoD type

PFAM

PF00061
PF08212
PF03973

PRINTS

PR00179
PR01171
PR01219
PR01273

PIRSF

PIRSF036893

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt