InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RDX

Summary

InnateDB Protein

IDBP-70607.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RDX

Protein Name

radixin

Synonyms

DFNB24;

Species

Homo sapiens

Ensembl Protein

ENSP00000342830

InnateDB Gene

IDBG-70605 (RDX)

Protein Structure

UniProt Annotation

Function

Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane.

Subcellular Localization

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cleavage furrow. Note=Highly concentrated in the undercoat of the cell-to-cell adherens junction and the cleavage furrow in the interphase and mitotic phase, respectively.

Disease Associations

Deafness, autosomal recessive, 24 (DFNB24) [MIM:611022]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. {ECO:0000269PubMed:17226784}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	37 [view]
Protein-Protein	37 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0007010	cytoskeleton organization
GO:0010628	positive regulation of gene expression
GO:0051693	actin filament capping
GO:0061028	establishment of endothelial barrier

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005925	focal adhesion
GO:0019898	extrinsic component of membrane
GO:0032154	cleavage furrow
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000299 FERM domain
IPR000798 Ezrin/radixin/moesin like
IPR008954 Moesin tail domain
IPR011174 Ezrin/radixin/moesin
IPR011259 Ezrin/radixin/moesin, C-terminal
IPR013992 Adenylate cyclase-associated CAP, N-terminal
IPR018979 FERM, N-terminal
IPR018980 FERM, C-terminal PH-like domain
IPR019748 FERM central domain
IPR019749 Band 4.1 domain
IPR019750 Band 4.1 family
IPR029071 Ubiquitin-related domain

PFAM

PF00769
PF01213
PF09379
PF09380
PF00373

PRINTS

PR00661
PR00935

PIRSF

PIRSF002305

SMART

SM00295

TIGRFAMs

Post-translational Modifications

Modification

Cross-References