Version 5.4
Homo sapiens Protein: GDA
Summary
InnateDB Protein IDBP-70610.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GDA
Protein Name guanine deaminase
Synonyms CYPIN; GUANASE; NEDASIN;
Species Homo sapiens
Ensembl Protein ENSP00000351170
InnateDB Gene IDBG-70608 (GDA)
Protein Structure
UniProt Annotation
Function Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia. {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 22 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008270 zinc ion binding
GO:0008892 guanine deaminase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006144 purine nucleobase metabolic process
GO:0006147 guanine catabolic process
GO:0006195 purine nucleotide catabolic process
GO:0007399 nervous system development
GO:0044281 small molecule metabolic process
GO:0055086 nucleobase-containing small molecule metabolic process
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR006680 Amidohydrolase 1
IPR014311 Guanine deaminase
PFAM PF01979
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y2T3
PhosphoSite PhosphoSite-Q9Y2T3
TrEMBL B4DIP8
UniProt Splice Variant
Entrez Gene 9615
UniGene Hs.700124
RefSeq NP_004284
HUGO HGNC:4212
OMIM 139260
CCDS CCDS6641
HPRD 08849
IMGT
EMBL AB033084 AF019638 AF095286 AF144745 AK097540 AK295716 AK300418 AK315988 AL135924 AL583829 AL590311 BC053584 CH471089
GenPept AAD25978 AAF13301 AAG40469 AAH53584 BAA86572 BAG53485 BAG58560 BAG62147 BAH14359 CAI12631 CAI16261 EAW62529 EAW62530

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca