InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZFAND5

Summary

InnateDB Protein

IDBP-70782.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZFAND5

Protein Name

zinc finger, AN1-type domain 5

Synonyms

ZA20D2; ZFAND5A; ZNF216;

Species

Homo sapiens

Ensembl Protein

ENSP00000366159

InnateDB Gene

IDBG-70778 (ZFAND5)

Protein Structure

UniProt Annotation

Function

Involved in protein degradation via the ubiquitin- proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4- induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation. {ECO:0000269PubMed:14754897}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in skeletal muscle. Expressed in fetal cochlea. Also expressed in infant brain, fetal heart, pancreatic islet, melanocyte, pineal gland, placenta, corneal stroma, and parathyroid tumor. Weakly expressed or undetectable in adult brain, heart, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes. Expressed in rhabdomyosarcoma RD cells (at protein level). {ECO:0000269PubMed:14754897, ECO:0000269PubMed:9758550}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.