InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CYTH1

Summary

InnateDB Protein

IDBP-70856.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYTH1

Protein Name

cytohesin 1

Synonyms

B2-1; CYTOHESIN-1; D17S811E; PSCD1; SEC7;

Species

Homo sapiens

Ensembl Protein

ENSP00000354398

InnateDB Gene

IDBG-70852 (CYTH1)

Protein Structure

UniProt Annotation

Function

Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP. {ECO:0000269PubMed:10652308, ECO:0000269PubMed:9653114}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:17398095}; Peripheral membrane protein {ECO:0000269PubMed:17398095}. Cytoplasm, cytosol {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005086	ARF guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0008289	lipid binding

Biological Process

GO:0030155	regulation of cell adhesion
GO:0032012	regulation of ARF protein signal transduction
GO:0043547	positive regulation of GTPase activity
GO:0090162	establishment of epithelial cell polarity

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005923	tight junction
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane