InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TIMP2

Summary

InnateDB Protein

IDBP-70965.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TIMP2

Protein Name

TIMP metallopeptidase inhibitor 2

Synonyms

CSC-21K; DDC8;

Species

Homo sapiens

Ensembl Protein

ENSP00000262768

InnateDB Gene

IDBG-70963 (TIMP2)

Protein Structure

UniProt Annotation

Function

Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19. {ECO:0000269PubMed:11710594, ECO:0000269PubMed:2554304, ECO:0000269PubMed:2793861}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0008047	enzyme activator activity
GO:0008191	metalloendopeptidase inhibitor activity
GO:0046872	metal ion binding

Biological Process

GO:0007417	central nervous system development
GO:0007568	aging
GO:0008152	metabolic process
GO:0008285	negative regulation of cell proliferation
GO:0010951	negative regulation of endopeptidase activity
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0030814	regulation of cAMP metabolic process
GO:0032487	regulation of Rap protein signal transduction
GO:0034097	response to cytokine
GO:0042493	response to drug
GO:0043408	regulation of MAPK cascade
GO:0043410	positive regulation of MAPK cascade
GO:0045664	regulation of neuron differentiation
GO:0045666	positive regulation of neuron differentiation
GO:0045762	positive regulation of adenylate cyclase activity
GO:0045861	negative regulation of proteolysis
GO:0045930	negative regulation of mitotic cell cycle
GO:0046580	negative regulation of Ras protein signal transduction
GO:0071310	cellular response to organic substance

Cellular Component

GO:0005576	extracellular region
GO:0005604	basement membrane
GO:0005615	extracellular space
GO:0009986	cell surface
GO:0030426	growth cone
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001134 Netrin domain
IPR001820 Proteinase inhibitor I35, tissue inhibitor of metalloproteinase
IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold

PFAM

PF00965

PRINTS

PIRSF

SMART

SM00206

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P16035