InnateDB Protein
|
IDBP-710868.3
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Ttll5
|
Protein Name
|
|
Synonyms
|
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000134971
|
InnateDB Gene
|
IDBG-158796 (Ttll5)
|
Protein Structure
|
|
Function |
Polyglutamylase which preferentially modifies alpha- tubulin. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step. Required for CCSAP localization to both spindle and cilia microtubules. Increases the effects of NCOA2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction. {ECO:0000269PubMed:17499049}.
|
Subcellular Localization |
Cell projection, cilium {ECO:0000269PubMed:17499049}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269PubMed:17499049}. Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=In ciliated cells, located in both cilia and basal bodies. In osteosarcoma cells, found in both cytoplasm and nucleus in the absence of steroid but located exclusively in the nucleus in the presence of steroid (By similarity). {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
Widely expressed with highest levels in brain, kidney, liver, spleen and testis. {ECO:0000269PubMed:17499049}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
|
Predicted by orthology |
Total |
5 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
MGI:2443657
|
InterPro |
IPR004344
Tubulin-tyrosine ligase/Tubulin polyglutamylase
|
PFAM |
PF03133
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q8CHB8
|
PhosphoSite |
PhosphoSite-Q8CHB8
|
TrEMBL |
H3BJC2
|
UniProt Splice Variant |
|
Entrez Gene |
320244
|
UniGene |
Mm.487639
|
RefSeq |
|
MGI ID |
|
MGI Symbol |
Ttll5
|
OMIM |
|
CCDS |
|
HPRD |
|
IMGT |
|
EMBL |
AB093278
AC134328
AC138303
AK006726
AK009255
AK028083
AM690748
BC035276
|
GenPept |
AAH35276
BAB24715
BAC25741
BAC41462
BAE43213
CAM84325
|
|
|