InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MICALL1

Summary

InnateDB Protein

IDBP-7155.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MICALL1

Protein Name

MICAL-like 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000215957

InnateDB Gene

IDBG-7153 (MICALL1)

Protein Structure

UniProt Annotation

Function

Probable lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, may act as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation. May be involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking. Alternatively, may regulate slow endocytic recycling of endocytosed proteins back to the plasma membrane. May indirectly play a role in neurite outgrowth. {ECO:0000269PubMed:19864458, ECO:0000269PubMed:20801876, ECO:0000269PubMed:21795389, ECO:0000269PubMed:23596323}.

Subcellular Localization

Recycling endosome membrane; Peripheral membrane protein. Late endosome membrane. Note=Localization to late endosomes is actin-dependent. Association to tubular recycling endosomes is regulated by RAB35 and ARF6.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0017137	Rab GTPase binding
GO:0042802	identical protein binding
GO:0070300	phosphatidic acid binding

Biological Process

GO:0006612	protein targeting to membrane
GO:0006897	endocytosis
GO:0006898	receptor-mediated endocytosis
GO:0031175	neuron projection development
GO:0032456	endocytic recycling
GO:0032458	slow endocytic recycling
GO:0036010	protein localization to endosome
GO:0097320	membrane tubulation
GO:1990090	cellular response to nerve growth factor stimulus
GO:1990126	retrograde transport, endosome to plasma membrane

Cellular Component

GO:0005770	late endosome
GO:0010008	endosome membrane
GO:0019898	extrinsic component of membrane
GO:0031902	late endosome membrane
GO:0055038	recycling endosome membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001715 Calponin homology domain
IPR001781 Zinc finger, LIM-type
IPR022613 Calmodulin-regulated spectrin-associated protein, CH domain
IPR022735 Domain of unknown function DUF3585

PFAM

PF00307
PF00412
PF11971
PF12130

PRINTS

PIRSF

SMART

SM00033
SM00132

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8N3F8