InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARHGAP15

Summary

InnateDB Protein

IDBP-71607.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARHGAP15

Protein Name

Rho GTPase activating protein 15

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000295095

InnateDB Gene

IDBG-71605 (ARHGAP15)

Protein Structure

UniProt Annotation

Function

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction. {ECO:0000269PubMed:12650940}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:12650940}. Membrane {ECO:0000269PubMed:12650940}; Peripheral membrane protein {ECO:0000269PubMed:12650940}.

Disease Associations

Tissue Specificity

Expressed in lung, liver and lymphoid cells. {ECO:0000269PubMed:12650940}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0030675	Rac GTPase activator activity

Biological Process

GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0008360	regulation of cell shape
GO:0032855	positive regulation of Rac GTPase activity
GO:0045087	innate immune response (InnateDB)
GO:0051056	regulation of small GTPase mediated signal transduction