InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mcl1

Summary

InnateDB Protein

IDBP-716398.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mcl1

Protein Name

Synonyms

AW556805; Mcl-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000135915

InnateDB Gene

IDBG-173221 (Mcl1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.

Experimentally validated
Total	37 [view]
Protein-Protein	35 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	43 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity
GO:0051434	BH3 domain binding

Biological Process

GO:0007275	multicellular organismal development
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008637	apoptotic mitochondrial changes
GO:0030154	cell differentiation
GO:0034097	response to cytokine
GO:0042981	regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand
GO:0097194	execution phase of apoptosis
GO:2000811	negative regulation of anoikis
GO:2001020	regulation of response to DNA damage stimulus
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005759	mitochondrial matrix
GO:0005829	cytosol
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0097136	Bcl-2 family protein complex