InnateDB Protein
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IDBP-716689.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CDKN2A
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Protein Name
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Synonyms
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ARF; CDK4I; CDKN2; CMM2; INK4; INK4A; MLM; MTS-1; MTS1; P14; P14ARF; P16; P16-INK4A; P16INK4; P16INK4A; P19; P19ARF; TP16;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000462950
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InnateDB Gene
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IDBG-54547 (CDKN2A)
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Protein Structure
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Function |
Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2- induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation. Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing. Interacts with COMMD1 and promotes its 'Lys63'-linked polyubiquitination. Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1. Binds to HUWE1 and represses its ubiquitin ligase activity. May play a role in controlling cell proliferation and apoptosis during mammary gland development. Isoform 6 may be involved in regulation of autophagy and caspase-independent cell death; the short-lived mitochondrial isoform is stabilized by C1QBP. {ECO:0000269PubMed:11314011, ECO:0000269PubMed:11314038, ECO:0000269PubMed:12660818, ECO:0000269PubMed:14636574, ECO:0000269PubMed:15361825, ECO:0000269PubMed:15567177, ECO:0000269PubMed:15876874, ECO:0000269PubMed:15989956, ECO:0000269PubMed:18305112, ECO:0000269PubMed:9724636}.
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Subcellular Localization |
Nucleus, nucleolus {ECO:0000269PubMed:18305112}. Nucleus, nucleoplasm {ECO:0000269PubMed:18305112}.Isoform 6: Mitochondrion {ECO:0000269PubMed:16713577}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 200 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
200
[view]
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Protein-Protein |
195
[view]
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Protein-DNA |
5
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0000209
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protein polyubiquitination
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GO:0006351
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transcription, DNA-templated
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GO:0006364
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rRNA processing
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GO:0006469
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negative regulation of protein kinase activity
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GO:0006919
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activation of cysteine-type endopeptidase activity involved in apoptotic process
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GO:0007050
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cell cycle arrest
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GO:0008285
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negative regulation of cell proliferation
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GO:0008637
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apoptotic mitochondrial changes
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GO:0010389
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regulation of G2/M transition of mitotic cell cycle
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GO:0030889
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negative regulation of B cell proliferation
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GO:0031647
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regulation of protein stability
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GO:0031648
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protein destabilization
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GO:0033088
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negative regulation of immature T cell proliferation in thymus
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GO:0033235
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positive regulation of protein sumoylation
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GO:0043517
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positive regulation of DNA damage response, signal transduction by p53 class mediator
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GO:0045087
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innate immune response (InnateDB)
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GO:0045893
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positive regulation of transcription, DNA-templated
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:0046825
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regulation of protein export from nucleus
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GO:0048103
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somatic stem cell division
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GO:0050821
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protein stabilization
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GO:0051444
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negative regulation of ubiquitin-protein transferase activity
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GO:0070534
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protein K63-linked ubiquitination
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GO:0071158
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positive regulation of cell cycle arrest
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GO:0090398
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cellular senescence
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GO:1902510
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regulation of apoptotic DNA fragmentation
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Cellular Component |
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PDB ID |
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InterPro |
IPR010868
Cyclin-dependent kinase inhibitor 2A
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PFAM |
PF07392
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8N726
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PhosphoSite |
PhosphoSite-Q8N726
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TrEMBL |
Q5ZEY9
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UniProt Splice Variant |
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Entrez Gene |
1029
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UniGene |
Hs.661650
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RefSeq |
NP_478102
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HUGO |
HGNC:1787
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OMIM |
600160
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CCDS |
CCDS6511
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HPRD |
02542
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IMGT |
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EMBL |
AF527803
AJ844636
AL449423
BC015960
BC021998
BT007020
CH471071
S78535
U26727
U38945
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GenPept |
AAA82236
AAB01737
AAC60649
AAH15960
AAH21998
AAM77919
AAP35666
CAH59950
CAH70601
EAW58600
EAW58601
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