InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CDKN2A

Summary

InnateDB Protein

IDBP-716939.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDKN2A

Protein Name

Synonyms

ARF; CDK4I; CDKN2; CMM2; INK4; INK4A; MLM; MTS-1; MTS1; P14; P14ARF; P16; P16-INK4A; P16INK4; P16INK4A; P19; P19ARF; TP16;

Species

Homo sapiens

Ensembl Protein

ENSP00000467390

InnateDB Gene

IDBG-54547 (CDKN2A)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 200 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0044822	poly(A) RNA binding
GO:0051059	NF-kappaB binding

Biological Process

GO:0000075	cell cycle checkpoint
GO:0000082	G1/S transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0001953	negative regulation of cell-matrix adhesion
GO:0007050	cell cycle arrest
GO:0007265	Ras protein signal transduction
GO:0008285	negative regulation of cell proliferation
GO:0030308	negative regulation of cell growth
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0034393	positive regulation of smooth muscle cell apoptotic process
GO:0035986	senescence-associated heterochromatin focus assembly
GO:0042326	negative regulation of phosphorylation
GO:0045087	innate immune response (InnateDB)
GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045892	negative regulation of transcription, DNA-templated
GO:0090399	replicative senescence
GO:2000111	positive regulation of macrophage apoptotic process
GO:2000774	positive regulation of cellular senescence