Version 5.4
Homo sapiens Protein: TRO
Summary
InnateDB Protein IDBP-71754.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRO
Protein Name trophinin
Synonyms MAGE-d3; MAGED3;
Species Homo sapiens
Ensembl Protein ENSP00000364162
InnateDB Gene IDBG-71746 (TRO)
Protein Structure
UniProt Annotation
Function Could be involved with bystin and tastin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation. Directly responsible for homophilic cell adhesion.
Subcellular Localization
Disease Associations
Tissue Specificity Strong expression at implantation sites. Found in the placenta from the sixth week of pregnancy. Was localized in the cytoplasm of the syncytiotrophoblast in the chorionic villi and in endometrial decidual cells at the uteroplacental interface. After week 10, the level decreased and then disappeared from placental villi. Also found in macrophages.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007156 homophilic cell adhesion
GO:0007566 embryo implantation
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR002190 MAGE protein
PFAM PF01454
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q12816
PhosphoSite PhosphoSite-Q12816
TrEMBL E7ERU6
UniProt Splice Variant
Entrez Gene 7216
UniGene Hs.743294
RefSeq NP_808224
HUGO HGNC:12326
OMIM 300132
CCDS CCDS43958
HPRD 02134
IMGT
EMBL AB029037 AK027489 AL049732 CH471154 U04811
GenPept AAA79334 BAA83066 BAB55149 CAB86651 CAM26850 EAW93200 EAW93201 EAW93205

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca