InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ect2

Summary

InnateDB Protein

IDBP-717656.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ect2

Protein Name

Synonyms

AI528536; mKIAA4037;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000135630

InnateDB Gene

IDBG-134125 (Ect2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 137 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	137 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0017048	Rho GTPase binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0000902	cell morphogenesis
GO:0000910	cytokinesis
GO:0007165	signal transduction
GO:0032147	activation of protein kinase activity
GO:0032467	positive regulation of cytokinesis
GO:0032863	activation of Rac GTPase activity
GO:0043065	positive regulation of apoptotic process
GO:0043089	positive regulation of Cdc42 GTPase activity
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045666	positive regulation of neuron differentiation
GO:0051260	protein homooligomerization
GO:0051988	regulation of attachment of spindle microtubules to kinetochore
GO:0070301	cellular response to hydrogen peroxide
GO:0070830	tight junction assembly
GO:0071277	cellular response to calcium ion
GO:0071479	cellular response to ionizing radiation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005923	tight junction
GO:0030496	midbody
GO:0032154	cleavage furrow
GO:0097149	centralspindlin complex

Protein Structure and Domains

PDB ID

MGI:95281

InterPro

IPR001357 BRCT domain

PFAM

PF00533
PF12738

PRINTS

PIRSF

SMART

SM00292

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

H3BL29

UniProt Splice Variant

Entrez Gene

13605

UniGene

Mm.436438

RefSeq

MGI ID

MGI Symbol

Ect2

OMIM

CCDS

HPRD

IMGT

EMBL

AC121099 AC165280

GenPept