Version 5.4
| Homo sapiens Protein: TMPRSS5 | |||||||||||
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| Summary | |||||||||||
| InnateDB Protein | IDBP-71779.5 | ||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
| Gene Symbol | TMPRSS5 | ||||||||||
| Protein Name | transmembrane protease, serine 5 | ||||||||||
| Synonyms | |||||||||||
| Species | Homo sapiens | ||||||||||
| Ensembl Protein | ENSP00000299882 | ||||||||||
| InnateDB Gene | IDBG-71777 (TMPRSS5) | ||||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||||
| Function | May play a role in hearing. {ECO:0000269PubMed:17918732}. | ||||||||||
| Subcellular Localization | Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. | ||||||||||
| Disease Associations | Note=Defects in TMPRSS5 may be a cause of deafness. | ||||||||||
| Tissue Specificity | Brain-specific. Predominantly expressed in neurons, in their axons, and at the synapses of motoneurons in the spinal cord. | ||||||||||
| Comments | |||||||||||
| Interactions | |||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||||
| PDB ID | |||||||||||
| InterPro |
IPR001254
Peptidase S1 IPR001314 Peptidase S1A, chymotrypsin-type IPR009003 Trypsin-like cysteine/serine peptidase domain IPR017448 SRCR-like domain |
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| PFAM |
PF00089
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| PRINTS |
PR00722
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| PIRSF | |||||||||||
| SMART |
SM00020
SM00202 |
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| TIGRFAMs | |||||||||||
| Post-translational Modifications | |||||||||||
| Modification | |||||||||||
| Cross-References | |||||||||||
| SwissProt | Q9H3S3 | ||||||||||
| PhosphoSite | PhosphoSite- | ||||||||||
| TrEMBL | G5EA43 | ||||||||||
| UniProt Splice Variant | |||||||||||
| Entrez Gene | 80975 | ||||||||||
| UniGene | |||||||||||
| RefSeq | NP_110397 | ||||||||||
| HUGO | HGNC:14908 | ||||||||||
| OMIM | 606751 | ||||||||||
| CCDS | CCDS44735 | ||||||||||
| HPRD | 05995 | ||||||||||
| IMGT | |||||||||||
| EMBL | AB028140 AP002436 AP003402 CH471065 EF445039 | ||||||||||
| GenPept | ACA06089 BAB20375 EAW67227 | ||||||||||