InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PFKFB1

Summary

InnateDB Protein

IDBP-71929.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PFKFB1

Protein Name

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1

Synonyms

F6PK; HL2K; PFRX;

Species

Homo sapiens

Ensembl Protein

ENSP00000364145

InnateDB Gene

IDBG-71927 (PFKFB1)

Protein Structure

UniProt Annotation

Function

Synthesis and degradation of fructose 2,6-bisphosphate.

Subcellular Localization

Disease Associations

Tissue Specificity

Liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003873	6-phosphofructo-2-kinase activity
GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0019900	kinase binding
GO:0042802	identical protein binding
GO:0070095	fructose-6-phosphate binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006000	fructose metabolic process
GO:0006003	fructose 2,6-bisphosphate metabolic process
GO:0006006	glucose metabolic process
GO:0006094	gluconeogenesis
GO:0006096	glycolytic process
GO:0006112	energy reserve metabolic process
GO:0016311	dephosphorylation
GO:0031100	organ regeneration
GO:0032868	response to insulin
GO:0033133	positive regulation of glucokinase activity
GO:0033762	response to glucagon
GO:0035556	intracellular signal transduction
GO:0042594	response to starvation
GO:0044281	small molecule metabolic process
GO:0046835	carbohydrate phosphorylation
GO:0051384	response to glucocorticoid
GO:0051591	response to cAMP

Cellular Component

GO:0005829	cytosol
GO:0043540	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex

Protein Structure and Domains

PDB ID

InterPro

IPR003094 Fructose-2,6-bisphosphatase
IPR010488 Zeta toxin domain
IPR013078 Histidine phosphatase superfamily, clade-1
IPR013079 6-phosphofructo-2-kinase
IPR016260 Bifunctional 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphate 2-phosphatase
IPR027417 P-loop containing nucleoside triphosphate hydrolase
IPR029033 Histidine phosphatase superfamily

PFAM

PF06414
PF00300
PF01591

PRINTS

PR00991

PIRSF

PIRSF000709

SMART

SM00855

TIGRFAMs

Post-translational Modifications

Modification

Cross-References