InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: REXO2

Summary

InnateDB Protein

IDBP-72146.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

REXO2

Protein Name

REX2, RNA exonuclease 2 homolog (S. cerevisiae)

Synonyms

REX2; RFN; SFN;

Species

Homo sapiens

Ensembl Protein

ENSP00000265881

InnateDB Gene

IDBG-72144 (REXO2)

Protein Structure

UniProt Annotation

Function

3'-to-5' exoribonuclease specific for small oligoribonucleotides. Active on small (primarily

Subcellular Localization

Isoform 1: Mitochondrion intermembrane space. Mitochondrion matrix.Isoform 2: Nucleus.Isoform 3: Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0004527	exonuclease activity
GO:0008408	3'-5' exonuclease activity

Biological Process

GO:0006139	nucleobase-containing compound metabolic process
GO:0009117	nucleotide metabolic process
GO:0090305	nucleic acid phosphodiester bond hydrolysis

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005739	mitochondrion
GO:0005758	mitochondrial intermembrane space
GO:0005759	mitochondrial matrix
GO:0005925	focal adhesion

Protein Structure and Domains

PDB ID

InterPro

IPR006055 Exonuclease
IPR012337 Ribonuclease H-like domain
IPR013520 Exonuclease, RNase T/DNA polymerase III

PFAM

PF00929

PRINTS

PIRSF

SMART

SM00479

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Y3B8

PhosphoSite

PhosphoSite-Q9Y3B8

TrEMBL

UniProt Splice Variant

Entrez Gene

25996

UniGene

Hs.740182

RefSeq

NP_056338

HUGO

HGNC:17851

OMIM

607149

CCDS

CCDS8371

HPRD

06192

IMGT

EMBL

AF151872 AK223200 AK312042 AL110239 BC105024 BC105026 BC107887 BC143701 CH471065 CR533500

GenPept

AAD34109 AAI05025 AAI05027 AAI07888 AAI43702 BAD96920 BAG34979 CAB53690 CAG38531 EAW67250