InnateDB Protein
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IDBP-721984.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RGS1
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Protein Name
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Synonyms
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1R20; BL34; HEL-S-87; IER1; IR20;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000464323
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InnateDB Gene
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IDBG-105443 (RGS1)
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Protein Structure
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Function |
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. This protein may be involved in the regulation of B-cell activation and proliferation.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
B-cell specific. Expression is relatively low in B-cells and chronic lymphocytic leukemia B-cells; however, in other types of malignant B-cell such as non-Hodgkin lymphoma and hairy cell leukemia, expression is constitutively high.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
7
[view]
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Protein-Protein |
7
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
GO:0006955
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immune response
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GO:0007165
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signal transduction
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GO:0007193
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adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
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GO:0008277
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regulation of G-protein coupled receptor protein signaling pathway
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GO:0038032
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termination of G-protein coupled receptor signaling pathway
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GO:0043547
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positive regulation of GTPase activity
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Cellular Component |
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PDB ID |
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InterPro |
IPR000342
Regulator of G protein signalling domain
IPR016137
Regulator of G protein signalling superfamily
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PFAM |
PF00615
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PRINTS |
PR01301
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PIRSF |
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SMART |
SM00315
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TIGRFAMs |
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Modification |
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SwissProt |
Q08116
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PhosphoSite |
PhosphoSite-Q08116
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
5996
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UniGene |
Hs.75256
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RefSeq |
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HUGO |
HGNC:9991
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OMIM |
600323
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CCDS |
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HPRD |
15968
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IMGT |
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EMBL |
AF493925
AK303138
AK315607
AL136987
BC015510
BT006668
S59049
X73427
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GenPept |
AAB26289
AAH15510
AAM12639
AAP35314
BAG37976
BAG64242
CAA51826
CAC19805
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