Version 5.4
Homo sapiens Protein: C17orf70
Summary
InnateDB Protein IDBP-72345.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol C17orf70
Protein Name chromosome 17 open reading frame 70
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000333283
InnateDB Gene IDBG-72343 (C17orf70)
Protein Structure
UniProt Annotation
Function Plays a role in Fanconi anemia-associated DNA damage response network. Regulates FANCD2 monoubiquitination and the stability of the FA core complex. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. {ECO:0000269PubMed:17396147}.
Subcellular Localization Nucleus {ECO:0000269PubMed:17396147}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
Biological Process
GO:0006281 DNA repair
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0043240 Fanconi anaemia nuclear complex
GO:0045111 intermediate filament cytoskeleton
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q0VG06
PhosphoSite PhosphoSite-Q0VG06
TrEMBL J3KQD8
UniProt Splice Variant
Entrez Gene 80233
UniGene Hs.548010
RefSeq NP_079437
HUGO HGNC:26171
OMIM 611301
CCDS CCDS32765
HPRD 07982
IMGT
EMBL AC137896 AK024644 AK025828 AL834374 BC001724 BC008883 BC021968 BC117139 BC117141 CR978826
GenPept AAH01724 AAH21968 AAI17140 AAI17142 BAB14944 BAB15251 CAD39037

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca