Version 5.4
| Mus musculus Protein: Ttc28 | |||||||
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| Summary | |||||||
| InnateDB Protein | IDBP-725187.3 | ||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
| Gene Symbol | Ttc28 | ||||||
| Protein Name | |||||||
| Synonyms | |||||||
| Species | Mus musculus | ||||||
| Ensembl Protein | ENSMUSP00000136116 | ||||||
| InnateDB Gene | IDBG-190708 (Ttc28) | ||||||
| Protein Structure |
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| UniProt Annotation | |||||||
| Function | During mitosis, may be involved in the condensation of spindle midzone microtubules, leading to the formation of midbody. {ECO:0000250}.Essential for the formation and integrity of the midbody. Max play a critical role in the progress of mitosis and cytokinesis during cell cycle (By similarity). {ECO:0000250}. | ||||||
| Subcellular Localization | Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}. Midbody {ECO:0000250}. Note=At interphase, localizes to centrosomes. At prometaphase and metaphase, associated with spindle microtubules and spindle poles. At anaphase, accumulates in the spindle midzone. At telophase, condensed on central spindles. During cytokinesis, condensed on the midbody where it colocalizes with AURKB (By similarity). {ECO:0000250}. | ||||||
| Disease Associations | |||||||
| Tissue Specificity | Expressed in embryos at all stages examined. In adult tissues, detected in heart and at low levels in kidney and testis. {ECO:0000269PubMed:23036704}. | ||||||
| Comments | |||||||
| Interactions | |||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||
| PDB ID | MGI:2140873 | ||||||
| InterPro |
IPR001440
Tetratricopeptide TPR1 IPR013026 Tetratricopeptide repeat-containing domain IPR013105 Tetratricopeptide TPR2 IPR019734 Tetratricopeptide repeat |
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| PFAM |
PF00515
PF07719 PF13174 PF13176 PF13181 |
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| PRINTS | |||||||
| PIRSF | |||||||
| SMART |
SM00028
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| TIGRFAMs | |||||||
| Post-translational Modifications | |||||||
| Modification | |||||||
| Cross-References | |||||||
| SwissProt | |||||||
| PhosphoSite | PhosphoSite-Q80XJ3 | ||||||
| TrEMBL | |||||||
| UniProt Splice Variant | |||||||
| Entrez Gene | 209683 | ||||||
| UniGene | Mm.398868 | ||||||
| RefSeq | |||||||
| MGI ID | |||||||
| MGI Symbol | Ttc28 | ||||||
| OMIM | |||||||
| CCDS | |||||||
| HPRD | |||||||
| IMGT | |||||||
| EMBL | |||||||
| GenPept | |||||||