InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SMAD7

Summary

InnateDB Protein

IDBP-725745.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SMAD7

Protein Name

Synonyms

CRCS3; MADH7; MADH8;

Species

Homo sapiens

Ensembl Protein

ENSP00000467621

InnateDB Gene

IDBG-3195 (SMAD7)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 161 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Experimentally validated
Total	161 [view]
Protein-Protein	144 [view]
Protein-DNA	9 [view]
Protein-RNA	0
DNA-DNA	8 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0030617	transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity
GO:0031625	ubiquitin protein ligase binding
GO:0034713	type I transforming growth factor beta receptor binding
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding
GO:0048185	activin binding
GO:0070411	I-SMAD binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0010467	gene expression
GO:0010719	negative regulation of epithelial to mesenchymal transition
GO:0010801	negative regulation of peptidyl-threonine phosphorylation
GO:0010944	negative regulation of transcription by competitive promoter binding
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway
GO:0022409	positive regulation of cell-cell adhesion
GO:0030336	negative regulation of cell migration
GO:0030509	BMP signaling pathway
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030514	negative regulation of BMP signaling pathway
GO:0031397	negative regulation of protein ubiquitination
GO:0031398	positive regulation of protein ubiquitination
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032925	regulation of activin receptor signaling pathway
GO:0033137	negative regulation of peptidyl-serine phosphorylation
GO:0034333	adherens junction assembly
GO:0034616	response to laminar fluid shear stress
GO:0034629	cellular protein complex localization
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048844	artery morphogenesis
GO:0050821	protein stabilization
GO:0051444	negative regulation of ubiquitin-protein transferase activity
GO:0055010	ventricular cardiac muscle tissue morphogenesis
GO:0055117	regulation of cardiac muscle contraction
GO:0060373	regulation of ventricular cardiac muscle cell membrane depolarization
GO:0060389	pathway-restricted SMAD protein phosphorylation
GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation
GO:0060412	ventricular septum morphogenesis
GO:0071560	cellular response to transforming growth factor beta stimulus

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005667	transcription factor complex
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005913	cell-cell adherens junction
GO:0016342	catenin complex
GO:0043234	protein complex