InnateDB Protein
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IDBP-725979.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MBD2
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Protein Name
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Synonyms
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DMTase; NY-CO-41;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000464554
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InnateDB Gene
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IDBG-3532 (MBD2)
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Protein Structure
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Function |
Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters. {ECO:0000269PubMed:10471499, ECO:0000269PubMed:10947852, ECO:0000269PubMed:12665568, ECO:0000269PubMed:16415179, ECO:0000269PubMed:24307175, ECO:0000269PubMed:9774669}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:12183469, ECO:0000269PubMed:9774669}. Note=Nuclear, in discrete foci. Detected at replication foci in late S phase.
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Disease Associations |
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Tissue Specificity |
Highly expressed in brain, heart, kidney, stomach, testis and placenta. {ECO:0000269PubMed:10050851}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated |
Total |
56
[view]
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Protein-Protein |
47
[view]
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Protein-DNA |
9
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
5 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001739
Methyl-CpG DNA binding
IPR016177
DNA-binding domain
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PFAM |
PF01429
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PRINTS |
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PIRSF |
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SMART |
SM00391
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UBB5
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PhosphoSite |
PhosphoSite-Q9UBB5
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TrEMBL |
A0A024R2B8
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UniProt Splice Variant |
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Entrez Gene |
8932
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UniGene |
Hs.713852
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RefSeq |
NP_056647
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HUGO |
HGNC:6917
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OMIM |
603547
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CCDS |
CCDS45871
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HPRD |
04647
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IMGT |
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EMBL |
AF072242
AF072246
AF120988
AF120989
AF120990
AF120991
AF120992
AF120993
BC032638
CH471096
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GenPept |
AAC68871
AAC68875
AAD56596
AAD56597
AAH32638
EAW62998
EAW62999
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