InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UBQLN2

Summary

InnateDB Protein

IDBP-72603.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBQLN2

Protein Name

ubiquilin 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000345195

InnateDB Gene

IDBG-72599 (UBQLN2)

Protein Structure

UniProt Annotation

Function

Increases the half-life of proteins destined to be degraded by the proteasome; may modulate proteasome-mediated protein degradation. {ECO:0000269PubMed:10983987}.

Subcellular Localization

Cytoplasm. Nucleus. Note=Where it colocalizes with the proteasome. Associated with fibers in mitotic cells.

Disease Associations

Amyotrophic lateral sclerosis 15, with or without frontotemporal dementia (ALS15) [MIM:300857]: A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. Patients with ALS15 may develop frontotemporal dementia. {ECO:0000269PubMed:21857683, ECO:0000269PubMed:22560112, ECO:0000269PubMed:22717235, ECO:0000269PubMed:22892309}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 73 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	73 [view]
Protein-Protein	72 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003684	damaged DNA binding
GO:0005488	binding
GO:0005515	protein binding

Biological Process

GO:0006289	nucleotide-excision repair
GO:0008219	cell death
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000449 Ubiquitin-associated domain/translation elongation factor EF-Ts, N-terminal
IPR000626 Ubiquitin-like
IPR006636 Heat shock chaperonin-binding
IPR009060 UBA-like
IPR015360 XPC-binding domain
IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote
IPR016024 Armadillo-type fold
IPR022617 Rad60/SUMO-like domain
IPR029071 Ubiquitin-related domain

PFAM

PF00627
PF00240
PF14560
PF09280
PF11976

PRINTS

PIRSF

SMART

SM00213
SM00727
SM00165

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9UHD9