InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CHST9

Summary

InnateDB Protein

IDBP-726439.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHST9

Protein Name

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000464655

InnateDB Gene

IDBG-1858 (CHST9)

Protein Structure

UniProt Annotation

Function

Catalyzes the transfer of sulfate to position 4 of non- reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Participates in biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Has a higher activity toward carbonic anhydrase VI than toward lutropin. Only active against terminal GalNAcbeta1,GalNAcbeta. Isoform 2, but not isoform 1, is active toward chondroitin.

Subcellular Localization

Isoform 1: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.Isoform 2: Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

Highly expressed in trachea. Also expressed in fetal lung, adult pancreas, testis and salivary gland. Expressed at low level in pituitary gland, apex of the heart, adult lung, prostate and mammary gland. Weakly or not expressed in heart, liver and spinal cord. {ECO:0000269PubMed:11139592, ECO:0000269PubMed:11445554}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001537	N-acetylgalactosamine 4-O-sulfotransferase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006790	sulfur compound metabolic process
GO:0016051	carbohydrate biosynthetic process
GO:0030166	proteoglycan biosynthetic process
GO:0030203	glycosaminoglycan metabolic process
GO:0030204	chondroitin sulfate metabolic process
GO:0030206	chondroitin sulfate biosynthetic process
GO:0042446	hormone biosynthetic process
GO:0044281	small molecule metabolic process