InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MBP

Summary

InnateDB Protein

IDBP-726684.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MBP

Protein Name

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000462223

InnateDB Gene

IDBG-5288 (MBP)

Protein Structure

UniProt Annotation

Function

The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non- classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T- cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. {ECO:0000269PubMed:8544862}.

Subcellular Localization

Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic side of myelin.Isoform 3: Nucleus {ECO:0000269PubMed:22609403}. Note=Targeted to nucleus in oligodendrocytes.

Disease Associations

Note=The reduction in the surface charge of citrullinated and/or methylated MBP could result in a weakened attachment to the myelin membrane. This mechanism could be operative in demyelinating diseases such as chronical multiple sclerosis (MS), and fulminating MS (Marburg disease).

Tissue Specificity

MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system. {ECO:0000269PubMed:7504278}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 62 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	62 [view]
Protein-Protein	62 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019911	structural constituent of myelin sheath

Biological Process

GO:0006955	immune response
GO:0007268	synaptic transmission
GO:0007417	central nervous system development
GO:0008366	axon ensheathment
GO:0021762	substantia nigra development