InnateDB Protein
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IDBP-7283.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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DLGAP5
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Protein Name
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discs, large (Drosophila) homolog-associated protein 5
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Synonyms
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DLG7; HURP;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000247191
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InnateDB Gene
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IDBG-7279 (DLGAP5)
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Protein Structure
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Function |
Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. {ECO:0000269PubMed:12527899, ECO:0000269PubMed:14699157, ECO:0000269PubMed:15145941}.
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Subcellular Localization |
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=Localizes to the spindle in mitotic cells. Colocalizes with CDH1 at sites of cell-cell contact in intestinal epithelial cells.
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Disease Associations |
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Tissue Specificity |
Abundantly expressed in fetal liver. Expressed at lower levels in bone marrow, testis, colon, and placenta. {ECO:0000269PubMed:12527899}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
8
[view]
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Protein-Protein |
8
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR005026
Guanylate-kinase-associated protein
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PFAM |
PF03359
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q15398
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PhosphoSite |
PhosphoSite-Q15398
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TrEMBL |
G3V543
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UniProt Splice Variant |
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Entrez Gene |
9787
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UniGene |
Hs.77695
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RefSeq |
NP_055565
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HUGO |
HGNC:16864
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OMIM |
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CCDS |
CCDS9723
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HPRD |
06490
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IMGT |
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EMBL |
AB076695
AK299338
AL139316
BC010658
BC016276
BT007344
BX248255
CH471061
D13633
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GenPept |
AAH10658
AAH16276
AAP36008
BAA02797
BAB97376
BAG61340
CAD62583
EAW80664
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