InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UPP2

Summary

InnateDB Protein

IDBP-72988.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UPP2

Protein Name

uridine phosphorylase 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000005756

InnateDB Gene

IDBG-72986 (UPP2)

Protein Structure

UniProt Annotation

Function

Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Shows substrate specificity and accept uridine, deoxyuridine, and thymidine as well as the two pyrimidine nucleoside analogs 5-fluorouridine and 5-fluoro-2(')-deoxyuridine as substrates.

Subcellular Localization

Disease Associations

Tissue Specificity

Predominantly expressed in kidney. {ECO:0000269PubMed:12849978}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004850	uridine phosphorylase activity

Biological Process

GO:0006206	pyrimidine nucleobase metabolic process
GO:0009116	nucleoside metabolic process
GO:0009166	nucleotide catabolic process
GO:0043097	pyrimidine nucleoside salvage
GO:0044206	UMP salvage
GO:0044281	small molecule metabolic process
GO:0046108	uridine metabolic process
GO:0046135	pyrimidine nucleoside catabolic process
GO:0055086	nucleobase-containing small molecule metabolic process