InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SECTM1

Summary

InnateDB Protein

IDBP-73456.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SECTM1

Protein Name

secreted and transmembrane 1

Synonyms

K12;

Species

Homo sapiens

Ensembl Protein

ENSP00000269389

InnateDB Gene

IDBG-73454 (SECTM1)

Protein Structure

UniProt Annotation

Function

May be involved in thymocyte signaling. {ECO:0000269PubMed:15742156}.

Subcellular Localization

Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Secreted.

Disease Associations

Tissue Specificity

Detected at the highest levels in peripheral blood leukocytes and breast cancer cell lines. Found in leukocytes of the myeloid lineage, with the strongest expression observed in granulocytes and no detectable expression in lymphocytes. Expressed in thymic epithelial cells and fibroblasts. {ECO:0000269PubMed:15742156, ECO:0000269PubMed:9480746}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005125	cytokine activity

Biological Process

GO:0006955	immune response
GO:0007165	signal transduction
GO:0007498	mesoderm development
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling

Cellular Component

GO:0005615	extracellular space
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome