InnateDB Protein
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IDBP-73675.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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EDA2R
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Protein Name
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ectodysplasin A2 receptor
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000363851
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InnateDB Gene
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IDBG-73673 (EDA2R)
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Protein Structure
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Function |
Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6. {ECO:0000269PubMed:12270937}.
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Subcellular Localization |
Membrane; Single-pass type III membrane protein.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
6
[view]
|
Protein-Protein |
6
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001368
TNFR/NGFR cysteine-rich region
IPR022319
Tumour necrosis factor receptor 27
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PFAM |
PF00020
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PRINTS |
PR01973
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PIRSF |
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SMART |
SM00208
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TIGRFAMs |
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Modification |
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SwissProt |
Q9HAV5
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PhosphoSite |
PhosphoSite-Q9HAV5
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
60401
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UniGene |
Hs.607657
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RefSeq |
NP_068555
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HUGO |
HGNC:17756
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OMIM |
300276
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CCDS |
CCDS14386
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HPRD |
02230
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IMGT |
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EMBL |
AF298812
AL353136
AY152724
AY358735
AY358736
BC034919
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GenPept |
AAG28761
AAH34919
AAN73210
AAQ89952
AAQ89953
CAH70433
CAH70434
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