InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FAP

Summary

InnateDB Protein

IDBP-73738.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FAP

Protein Name

fibroblast activation protein, alpha

Synonyms

DPPIV; FAPA;

Species

Homo sapiens

Ensembl Protein

ENSP00000188790

InnateDB Gene

IDBG-73736 (FAP)

Protein Structure

UniProt Annotation

Function

In association with DPP4 is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May have a role in tissue remodeling during development and wound healing, and may contribute to invasiveness in malignant cancers. {ECO:0000269PubMed:16651416}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:16651416}; Single-pass type II membrane protein {ECO:0000269PubMed:16651416}. Cell projection, lamellipodium membrane {ECO:0000269PubMed:16651416}; Single-pass type II membrane protein {ECO:0000269PubMed:16651416}. Cell projection, invadopodium membrane {ECO:0000269PubMed:16651416}; Single-pass type II membrane protein {ECO:0000269PubMed:16651416}. Note=Found in cell surface lamellipodia, invadopodia and on shed vesicles. Colocalized with DPP4 in invadopodia and lamellipodia of migratory activated endothelial cells in collagenous matrix. Colocalized with DPP4 on endothelial cells of capillary-like microvessels but not large vessels within invasive breast ductal carcinoma.

Disease Associations

Tissue Specificity

Fibroblast specific.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.

Experimentally validated
Total	24 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0004175	endopeptidase activity
GO:0004222	metalloendopeptidase activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008236	serine-type peptidase activity
GO:0008239	dipeptidyl-peptidase activity
GO:0042803	protein homodimerization activity
GO:0046983	protein dimerization activity

Biological Process

GO:0006508	proteolysis
GO:0010716	negative regulation of extracellular matrix disassembly
GO:0043542	endothelial cell migration
GO:0051917	regulation of fibrinolysis

Cellular Component

GO:0005615	extracellular space
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030027	lamellipodium
GO:0030054	cell junction
GO:0031258	lamellipodium membrane
GO:0045177	apical part of cell
GO:0045178	basal part of cell
GO:0071438	invadopodium membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001375 Peptidase S9, prolyl oligopeptidase, catalytic domain
IPR002469 Peptidase S9B, dipeptidylpeptidase IV N-terminal
IPR029058 Alpha/Beta hydrolase fold

PFAM

PF00326
PF00930

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q12884

PhosphoSite