InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IGBP1

Summary

InnateDB Protein

IDBP-74246.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IGBP1

Protein Name

immunoglobulin (CD79A) binding protein 1

Synonyms

ALPHA-4; IBP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000348784

InnateDB Gene

IDBG-74242 (IGBP1)

Protein Structure

UniProt Annotation

Function

Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of the phosphatases PP2A, PP4 and PP6 by protecting their partially folded catalytic subunits from degradative polyubiquitination until they associate with regulatory subunits. {ECO:0000269PubMed:19818709, ECO:0000269PubMed:23591866}.

Subcellular Localization

Cytoplasm {ECO:0000305}.

Disease Associations

Mental retardation, X-linked, syndromic, 28 (MRXS28) [MIM:300472]: A mental retardation syndrome characterized by agenesis of the corpus callosum, coloboma of the iris and optic nerve, severe retrognathia, and intellectual deficit. Mental retardation is defined by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. {ECO:0000269PubMed:14556245}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Ubiquitously expressed with highest levels in heart, skeletal muscle and pancreas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 133 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	133 [view]
Protein-Protein	129 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008601	protein phosphatase type 2A regulator activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0007165	signal transduction
GO:0009966	regulation of signal transduction
GO:0032873	negative regulation of stress-activated MAPK cascade
GO:0034612	response to tumor necrosis factor
GO:0042113	B cell activation
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0060632	regulation of microtubule-based movement
GO:0070555	response to interleukin-1