Version 5.4
Homo sapiens Protein: FAM21A
Summary
InnateDB Protein IDBP-74310.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FAM21A
Protein Name family with sequence similarity 21, member A
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000344037
InnateDB Gene IDBG-74308 (FAM21A)
Protein Structure
UniProt Annotation
Function Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting. In the complex, it probably mediates the recruitment of the complex to endosome membranes (By similarity). {ECO:0000250}.
Subcellular Localization Early endosome membrane {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0042147 retrograde transport, endosome to Golgi
Cellular Component
GO:0005769 early endosome
GO:0031901 early endosome membrane
GO:0071203 WASH complex
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q641Q2
PhosphoSite PhosphoSite-Q641Q2
TrEMBL Q9Y4N4
UniProt Splice Variant
Entrez Gene 387680
UniGene Hs.645272
RefSeq NP_001278327
HUGO HGNC:23416
OMIM
CCDS
HPRD 17364
IMGT
EMBL AL080183 AL442003 AL450382 BC065500 BC075815 BC082258
GenPept AAH65500 AAH75815 AAH82258 CAB45765 CAM17004 CAM22317

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca